TNF-α: Tumor Necrosis Factor-alpha (infliximab and adalimumab); JAK-STAT: Janus kinase/Signalling transducer of activators of transcription (ruxolitinib and tofacitinib); CS: Cutaneous sarcoidosis; CSAMI: Cutaneous Sarcoidosis Activity and Morphology Instrument. This evidence concerns the gene TNF and Cowden syndrome 1.