CX3CR1 and Alzheimer disease: Combining Cx3cr1 deletion, a triple-transgenic mouse model of AD (3xTg-AD: PS1M146V Kin, transgenic APPSwe and tauP301L), and two-photon microscopy, it was possible to evaluate simultaneously neuronal death and microglial cell behavior during a 28-d imaging in living mice (Fuhrmann et al., 2010).