LRRK2 and Parkinson disease: Transgenic PD models have been developed by overexpression of mutant genes for autosomal dominant genes such as α-synuclein and leucine rich repeat kinase 2 (LRRK2) and KO or Kdown models for autosomal recessive genes, such as Parkin, DJ-1, phosphatase and tensin homolog (PTEN)-induced novel kinase 1 (PINK1) (Dawson et al., 2010; Blesa et al., 2012; Angelopoulou et al., 2020).