Interestingly, aged albino mice with Cx3cr1 deletion exhibit, in regions of retinal degeneration, accumulation of microglia in the subretinal space associated with drusen-like yellowish-white dots, and increased choroidal neovascularization, histological findings like those found in patients with AMD (Combadiere et al., 2007). Here, CX3CR1 is linked to age-related macular degeneration.