In MS patients, Cx3cr1-Val249Ile polymorphisms revealed that Cx3cr1 Ile249 Thr280 haplotype could endow a protective effect by impairing the switch of MS from the relapsing–remitting type (RRMS) into the secondary progressive type (SPMS) (Stojkovic et al., 2012; Arli et al., 2013). The gene discussed is CX3CR1; the disease is myeloid sarcoma.