Univariate analysis revealed that Child-B, tumor number ≥ 2, tumor diameter ≥ 10 cm, AFP ≥ 400 ng/ml, ALP ≥ 125 U/L, platelet ≥ 100000/μL, ALT ≥ 40 U/L, worse BCLC stage, PVTT, and TACE were significant risk factors for death in this patient population. The gene discussed is AFP; the disease is neoplasm.