Subsequently, transcript levels of genes associated with hepatic fibrosis were assessed via qRT-PCR, which revealed a significant upregulation of fibrosis-related transcripts encoding proteins such as procollagen α1(I), TIMP-1, α-SMA (ACTA2), MMP-2, and MMP-9 in the livers of scurfy mice. This evidence concerns the gene MMP2 and Hepatic fibrosis.