This substantiates our findings in scurfy liver revealing a strong macrophage differentiation towards the M1 phenotype and a decreased M2-type polarization in a TNFα-dominated proinflammatory microenvironment (Figures 6, 7) Surprisingly, this contrasts with our previous research which showed M2-polarized macrophages and a significant Th2 deviation in the skin of scurfy mice, as partly found in scleroderma (56). Here, TNF is linked to scleroderma.