As such, type 1 AIH (AIH-1, classic type) is associated with ANA and anti-SMA, whereas the rarer, yet more aggressive forms AIH-2 and AIH-3 are defined by the existence of anti-LKM/anti-LC1 and anti-SLA autoantibodies, respectively (12, 37–39). The gene discussed is SMN1; the disease is autoimmune hepatitis.