The main mechanisms of interaction between tumor cells and tumour-associated macrophages are LGALS9-SLC1A5, CCR1_CCL23, CSF1R _CSF1, GRN_SORT1, CSF1_SIRPA, and SIRPA_CD47, which primarily induce macrophage differentiation to M2 type while inhibiting macrophage phagocytosis of tumor cells, cause immune escape, and promote tumor cell proliferation, invasion, and metastasis (31–35). The gene discussed is SIRPA; the disease is neoplasm.