ICAM1 and neoplasm: Among them, ICAM1_SPN plays an important role in cell-cell interactions, and circulating tumor cells with stem cell properties may be able to use the adhesion protein ICAM1 to promote the formation of circulating tumor clusters that migrate from the body’s primary tumor sites to other organs (39, 40); EPHA2 in EPHA2_EFNA5 induces inhibition of the focal adhesion kinase (FAK), extracellular regulatory protein kinases (ERK) and Akt phosphorylation, thereby regulating motility, viability and proliferation of a variety of malignant cell lines (41).