Moreover, the association between PLEKHA4 and prognosis was also validated using clinical samples of LGG (n=84) and GBM (n=96), and results clearly showed that a high PLEKHA4 expression was significantly related to adverse prognosis of LGG patients (HR=8.63, 95% CI=4.46-16.72, P<0.001), but not GBM (HR=1.21, 95% CI=0.08-1.83, P=0.373, Figures 3D). The gene discussed is PLEKHA4; the disease is glioblastoma.