PLEKHA4 and cancer: Thereafter, KEGG enrichment analysis with respect to PLEKHA4-binding partners was carried out, and results showed that proteoglycans in cancer, leukocyte transendothelial migration, and synaptic vesicle cycle are among the top hits (Supplementary Figure 9C), further strengthened the potential of PLEKHA4 in modulating immune response and TME formation.