∙TQ decrease in BGL, no further significant change was recorded with TQ + fluoxetine treatment.∙Significantly decreased immobility time∙Increased latency to immobility and locomotor activity∙TQ and fluoxetine combination reduced TBARS level and increased GSH content but did not affect antioxidant enzyme activities.∙Reduction in inflammatory markers (IL-1b, IL-6 and TNF-a)TQ + fluoxetine can be used to control depression. This evidence concerns the gene TNF and major depressive disorder.