KLK3 and prostate cancer: At present, the factors influencing the length of time it takes prostate cancer to progress to CRPC are not conclusive, factors such as age, Prostate Specific Antigen (PSA) level, Gleason score, T stage, and alkaline phosphatase level have been associated with the development of CRPC (Koo et al., 2015; Tan et al., 2021).