KLK3 and Familial prostate cancer: Previous studies have shown that factors such as initial PSA level, alkaline phosphatase, prostate volume, and Gleason score can affect the time it takes for prostate cancer to progress to CRPC (Nayyar, Sharma & Gupta, 2010; Benaim, Pace & Roehrborn, 2002; Ross et al., 2008).