However, studies have shown MS patients with the glial–lymphatic system impaired (37), cerebrospinal fluid and interstitial fluid return blocked, and interstitial clearance reduced, leading to the accumulation of inflammatory and neurotoxic elements, such as meningeal T cells and toxic cytokines (e.g., the chemokine ligand, the interferon-γ, the tumor necrosis factor, and lymphotoxin-α/β), resulting in neuronal swelling. Here, TNF is linked to myeloid sarcoma.