Necroptosis activation has been reported to correlate well with invasive phenotypes and poor prognosis in HNSCC; indeed, some necroptosis-related proteins, including RIPK1, RIPK3, and MLKL, have been found to be higher in mice with OSCC, suggesting that necroptosis is a crucial event in oral injuries (Wei et al., 2022). The gene discussed is RIPK1; the disease is head and neck squamous cell carcinoma.