Many clinical studies show that Leonurine inhibits lung cancer cell immune evasion and exerts anti-lung cancer effects by inhibiting the ILT4-PI3K/AKT-B7-H3 pathway in human lung cancer cells and down-regulating ILT4, PI3K, AKT, B7-H3 mRNA, and protein expression (Stroe and Oancea, 2020; Laurindo et al., 2023). This evidence concerns the gene CD276 and lung cancer.