In the milieu of crucial elements of BLS WIE, it should be noted that Rosmarinic acid (RA) is a key element detected in BLS WIE and significantly reduced TNF-α, IL-1β, IL 6, NO, p-JNK, p-p38 MAPK, and NF-kB when Rosmarinic acid was orally administered to streptozotocin (STZ)-induced type 2 Diabetes (T2D) Wistar rats (Govindaraj and Pillai, 2015). The gene discussed is MAPK8; the disease is type 2 diabetes mellitus.