CYP3A4 and familial hypercholesterolemia: Hu et al. [30] found no significant association between CYP3A4*1G and CYP3A4*22, along with other gene polymorphisms (CYP3A5*3 and PPARA rs4823613 A>G), with response to 40 mg simvastatin in 273 Chinese patients with hypercholesterolemia.