TOP2A and renal cell carcinoma: Transfecting of shTOP2A, miR-30c-2-3p inhibitor, and shTOP2A plus miR-30c-2-3p inhibitor, respectively, into 786-O, Caki-1, and ACHN cells allowed researchers to determine whether miR-30c-2-3p targets TOP2A to prevent RCC cell proliferation and trigger cell death.