HMOX1 and acute myeloid leukemia: It has been shown that the use of ferroptosis inducers generates large amounts of ROS in AML cells, which resist oxidative stress by activating NRFR/HO-1 through nuclear translocation of the NRF2 protein, and that downregulation of NRF2 expression markedly increases the killing effect of ferroptosis inhibitors (Ali et al., 2016).