It has been shown that the use of ferroptosis inducers generates large amounts of ROS in AML cells, which resist oxidative stress by activating NRFR/HO-1 through nuclear translocation of the NRF2 protein, and that downregulation of NRF2 expression markedly increases the killing effect of ferroptosis inhibitors (Ali et al., 2016). Here, NFE2L2 is linked to acute myeloid leukemia.