HMOX1 and acute myeloid leukemia: This is consistent with the results of another team’s experiments: downregulation of HO-1 by gene silencing and the classical HO-1 inhibitor ZnPPIX, which found that HO-1 silencing greatly sensitized AML cells to Zoerythromycin (Wei et al., 2014; Wei S. X. et al., 2015).