HMOX1 and acute myeloid leukemia: Numerous experiments have shown that HL60-resistant cells have higher expression of HO-1 than HL-60-sensitive cells, identifying a correlation between HO-1 overexpression and AML resistance, and subsequent experiments have hypothesized that it may be through a ROS-dependent pathway thereby allowing AML cells to escape chemotherapy-induced apoptosis (Zhe et al., 2015; Heasman et al., 2011).