As shown in Supplementary Figure 6A, the 50-month overall survival rate between the high and low expression groups of REEP3 (P = 0.001), REEP4 (P < 0.001), TEP1 (P < 0.001) and EEPD1 (P < 0.001) was significantly different in GBM patients. The gene discussed is EEPD1; the disease is glioblastoma.