Since SCs are the main players in the first days of Wallerian degeneration (WD) and are highly sensitive to metabolic alterations,16 we investigated some metabolic parameters (glycemia, insulin, glucagon and triglycerides serum levels) after peripheral nerve injury in male and female CD1 mice subjected to chronic constriction injury17 (CCI), which induces WD and allodynia in the ipsilateral hindpaw (Figures 1A and 1B) (all statistical analyses are reported in figures legend). This evidence concerns the gene INS and Wilson disease.