Kcr is a key to regulate cellular functions in both physiological and pathological states, such as DNA damage32 and repair,33 gametogenesis,34 sperm motility,35 endoderm differentiation,36osteogenic differentiation,37 neural development,12 pancreatic cancer progression,38 hepatocellular carcinoma progression,39 cardiac homeostasis,40 acute kidney injury,13 diabetic kidney disease,41 hepatic metabolism,15 glucose metabolism,42 and depression.43 The gene discussed is CLEC4F; the disease is acute kidney injury.