Kcr is a key to regulate cellular functions in both physiological and pathological states, such as DNA damage32 and repair,33 gametogenesis,34 sperm motility,35 endoderm differentiation,36osteogenic differentiation,37 neural development,12 pancreatic cancer progression,38 hepatocellular carcinoma progression,39 cardiac homeostasis,40 acute kidney injury,13 diabetic kidney disease,41 hepatic metabolism,15 glucose metabolism,42 and depression.43 This evidence concerns the gene CLEC4F and familial pancreatic carcinoma.