Decrotonylation of LONP1‐K390 suggests that regulating the specific Kcr sites of specific proteins, disrupts metabolic homeostasis in the ovarian micro‐environment by inhibiting LONP1‐mediated mitochondrial function, including the quality of oocytes, as evidenced by the observed reduction in mitochondrial transmembrane potential and elevation of MitoSOX in GV and MII oocytes of PCOS‐like mice. Here, CLEC4F is linked to polycystic ovary syndrome.