Even though liver biopsy remains the “golden standard” of diagnosis of liver fibrosis, studies have been devoted to investigating the role of some non-invasive biomarkers in diagnosing liver fibrosis, including the Fibrosis-4 index (FIB-4), which is calculated through common parameters (age, AST, ALT, and platelet counts). The gene discussed is GPT; the disease is Hepatic fibrosis.