Protein aggregation is a prominent pathology detected prior to neurodegeneration in PFN1 transgenic rats (Yuan et al., 2021), and is a shared hallmark of neurodegenerative diseases like ALS (Neumann et al., 2006; Kwong et al., 2007, 2008), Alzheimer’s disease (Bruggink et al., 2012), and Parkinson’s disease (Goedert et al., 2012). The gene discussed is PFN1; the disease is amyotrophic lateral sclerosis.