PFN1 and amyotrophic lateral sclerosis: Intriguingly, the overexpression of mutant, but not wildtype (WT), human PFN1 in mice and rats recapitulates the cardinal manifestations of ALS, encompassing progressive motor neuron degeneration, skeletal muscle denervation atrophy, and resultant paralysis (Yang et al., 2016; Fil et al., 2017; Yuan et al., 2021; Yusuf et al., 2022).