Analysis of these genes in our CLL cells (Supplementary Table S7) showed that ATF4, CHOP, and HSP90B1 mRNA expression was higher in NT1-M CLL compared to that in NT1-WT CLL (P = 0.008, P = 0.041, and P = 0.026, respectively) (Figure 1D). Here, HSP90B1 is linked to B-cell chronic lymphocytic leukemia.