BCL2 and B-cell chronic lymphocytic leukemia: WB analysis showed that in NT1-M CLL, curcumin reduced the levels of both MCL1 (P = 0.015) and BCL2 (P = 0.031) compared with those in DMSO, whereas in NT1-WT cells, it increased the levels of MCL1 (P = 0.015) without significantly influencing BCL2 expression (Figure 4E).