Based on the dose–effect curves of drugs alone and in combination, we calculated the DRI; we found that curcumin sensitized NT1-M CLL cells to the cytotoxic action of venetoclax and significantly decreased the efficacious dose of venetoclax.Curcumin elicited anti-leukemic effects associated with NOTCH1 inhibition in Eμ-TCL1 mice. This evidence concerns the gene NOTCH1 and B-cell chronic lymphocytic leukemia.