When we analyzed the effect of curcumin on caspase 4 and its downstream caspase 3, we found that both caspases were cleaved after curcumin treatment, but cleavage started earlier and was higher in NT1-M than in NT1-WT CLL cells (N = 4; Figure 2D). This evidence concerns the gene CASP4 and B-cell chronic lymphocytic leukemia.