In one tumor a clonal mutation (R45P) in Igfbp7 was identified along with a mutation (R2457S) in Igf2r and others in Ahctf1, Notch4, Ncoa3, and Nfe2l2. The other tumor had a Trp53 somatic missense mutation along with mutations in the driver genes Myh9, Kmt2d and Keap1. Although the genomic alterations were documented, the controls were from different mice making it a limitation in this study. The gene discussed is NOTCH4; the disease is neoplasm.