CD317 (also known as BST-2, HM1.24, or tetherin), a representative IFN-I-induced protein that is highly expressed in multiple tumor types42,43, inhibits IFN-I secretion from pDCs and alters the phenotype of pDCs by interacting with ILT-7 on pDCs41. This evidence concerns the gene LILRA4 and neoplasm.