In a mouse model of CLL, neutrophil functions are substantially altered, as they are more resistant to apoptosis and produce A proliferation-inducing ligand (APRIL) and B-cell-activating factor (BAFF), and are more prone to release neutrophil extracellular traps (NETs) that support the survival and proliferation of leukemic cells [14]. This evidence concerns the gene TNFSF13 and B-cell chronic lymphocytic leukemia.