Since galectins can affect host immune cells and pathogens during the infection process, and such two-faceted functions of galectins can render data interpretation difficult in vivo, we prepared pure and biologically active recombinant galectin proteins and investigated the effect of galectin-1, 2, and 3 on the motility of S. mansoni for the first time to assess their direct effect; we found no direct effect of galectins on the worm. The gene discussed is LGALS1; the disease is infection.