In the CT-cohort, tumors with SP142 IC ≥ 1% were significantly associated with higher NHG (p = 0.004), higher Ki-67 proliferation index (p = 0.005), histological medullary features (p = 0.001) and increased stromal TIL abundance (p < 0.001), whereas age at diagnosis, tumor size and lymph node status were not significantly associated with PD-L1 status (Table 2). This evidence concerns the gene CD274 and neoplasm.