NPPB and vascular disorder: Multivariable logistic regression analysis revealed that baseline NT-proBNP ≥ 1429.60 pg/ml (odds ratio [OR]: 0.257, 95% CI: 0.136 to 0.487, p < 0.001), peripheral vascular disease (OR: 2.537,95%CI:1.091 to 5.971, p = 0.031), left ventricular ejection fraction (OR: 1.042, 95%CI: 1.010 to 1.075 per 1%, p = 0.011), maximum velocity (OR:0.576, 95%CI: 0.414 to 0.801 per 1 m/s, p = 0.001) were independent determinants of NT-proBNP non-responders (Table 4).