Predictors of all-cause mortality in descending order of HR were NT-proBNP non-responders (HR:4.779, 95%CI:1.815–12.587, p = 0.002), NT-proBNP ≥ 1350.5 pg/ml at discharge (HR:4.218, 95%CI:1.340-13.279, p = 0.014), mitral regurgitation ≥ moderate (HR:3.064, 95%CI:1.046–8.973, p = 0.041), coronary artery disease (HR:2.974, 95%CI:1.131–7.821, p = 0.027), length of intensive care unit (HR:1.051, 95%CI:1.018 to 1.084 per 1 day, p = 0.002) according to multivariable Cox analysis. This evidence concerns the gene NPPB and Mitral regurgitation.