PPFIBP2 and cholangiocarcinoma: To identify potential downstream targets responsible for the oncogenic role of METTL16 in CCA, we performed m6A methylated RNA immunoprecipitation sequencing (MeRIP-seq) in human CCA cells (CCLP1 and HuCCT1) with or without CRISPR/Cas9-mediated METTL16 depletion.