METTL16 and cholangiocarcinoma: Consistent with METTL16 mediated regulation of PRDM15-FGFR4, our data revealed that depletion of METTL16 by its GapmeR antisense oligonucleotide (ASO) decreased the protein levels of PRDM15 and FGFR4 in CCA cells (Fig. 6F).