Through public data and experimental verification, we found that inhibiting the expression of EGR1 can regulate the invasion of tumour cells (Fig. 4), and the decreased expression of EGR1 significantly upregulated the expression of E-cadherin (Fig. 5) and downregulated the targeted genes FAS and HSPG2 (Fig. 6). The gene discussed is CDH1; the disease is neoplasm.