MTOR and chronic obstructive pulmonary disease: However, the pharmacological mechanisms of how ISOF elevates cAMP in COPD to exert anti-inflammatory and improve lung function effects, and how it reduces mTOR expression to keep T cell subpopulation homeostasis have not been investigated in detail.cAMP is an attractive drug target for the treatment of chronic airway diseases because it is one of the most important second messengers and plays a key role in relaxing airway smooth muscle and reducing inflammation [52].