In acute or chronic liver disease, hepatocytes could not respond to insulin signaling in a physiological way and resultant dysregulated glycogenolysis, gluconeogenesis, and lipogenesis promote hyperglycemia, systemic insulin resistance and eventually causing elevated risk of T2DM, of which NAFLD is the most prevalent type and lead to a nearly two-fold increased risk [68, 69]. The gene discussed is INS; the disease is Insulin resistance.