In the study, the polymorphisms of GSTP1 C341T, CAT A21T, CAT C262T, CYP 2E1 RsaI, SOD2 Ala 16 Val, SOD2 Val 9 Ala, SOD3 A213G with COPD risk were firstly analyzed. Here, SOD2 is linked to chronic obstructive pulmonary disease.