Progressive and sustained hypertension induced by AngII, a high-salt and high-fat diet, or monocrotaline treatment in model mice and rats was reversed by p38 inhibitors; similarly, endothelial dysfunction, vascular cell proliferation, cardiac hypertrophy, and enhanced extracellular matrix and collagen deposition leading to vascular remodelling were reversed [81, 83]. Here, AGT is linked to hypertensive disorder.