Furthermore, our findings were validated in a nude mouse model. However, past studies have demonstrated that TKT is overexpressed in patients receiving oxaliplatin chemotherapy, which may be related to the activation of the glucose metabolism pathways after the tumor cells are damaged [39]. Unfortunately, the correlation between TKT and oxaliplatin resistance is out of the scope of this study, and further investigation is needed. Here, TKT is linked to neoplasm.