TKT and cancer: Cancer cells induce metastasis and chemoresistance via increased glucose uptake and the creation of a more acidic tumor microenvironment [27]. By using MS and CO-IP, this study revealed, for the first time, that MND1 can be coexpressed with TKT. TKT is mainly involved in de novo nucleotide synthesis and pentose phosphate pathway toward the promotion of rapid cancer cell proliferation [28]. Furthermore, TKT can enhance oxidative stress as well as the proliferative and metastatic capacities of hepatoma cells in vitro and promote tumor progression by binding to the EGFR pathway [29].