E2F1 and cancer: As a meiotic regulatory protein, MND1 can form a complex with HOP2 to promote homologous chromosome pairing and meiotic double-strand break repair [8]. Meanwhile, the MND1-HOP2 complex can drive meiotic recombination into the interhomologous pathway, which replaces the telomere elongation mechanism in cancer cells [9]. MND1, Kruppel-like factor 6 (KLF6), and E2F transcription factor 1 (E2F1) can form a positive feedback loop to confer cisplatin resistance [10]. However, the role of MND1 in GC and oxaliplatin resistance remains unknown.