It has been reported that TKT activates the AKT expression via GRP78 phosphorylation [30]. Moreover, AKT can phosphorylate TKT at thr382 to promote its expression and purine synthesis [32]. Interestingly, TKT was significantly overexpressed in samples of oxaliplatin resistant colorectal cancer patients [32]. The gene discussed is AKT1; the disease is colorectal cancer.