It has been reported that TKT activates the AKT expression via GRP78 phosphorylation [30]. Moreover, AKT can phosphorylate TKT at thr382 to promote its expression and purine synthesis [32]. Interestingly, TKT was significantly overexpressed in samples of oxaliplatin resistant colorectal cancer patients [32]. Here, HSPA5 is linked to colorectal cancer.