In the model III, after full adjustment for cardiovascular disease risk factors (age, gender, BMI, Diabetes, Hypertension, Creatinine, UA, LDL-C, HbA1c), the risk of severe coronary atherosclerotic plaque burden gradually increased in the second (OR: 1.86; 95% CI: 1.21–2.88; P < 0.001), and third serum cystatin C tertiles (OR: 2.50; 95% CI: 1.59–3.01; P < 0.001) compared with the first serum cystatin C tertiles (As shown in Table 2). This evidence concerns the gene CST3 and diabetes mellitus.