Both the fixed-effect and random-effect IVW models showed that serum cystatin C level was associated with an increased risk of coronary atherosclerosis (OR, 1.004; 95% CI, 1.002–1.006, P < 0.001; OR, 1.004; 95% CI, 1.002–1.006, P < 0.001), as shown in Fig. 2. This evidence concerns the gene CST3 and coronary atherosclerosis.