CXCL8 and gastric cancer: While IL-8 production is primarily induced by the translocation of CagA through the type IV secretion system (Horridge et al. 2017; Odenbreit et al. 2000), OipA has also been shown to induce IL-8 production in neighbor epithelial cells and increase the risk of the development of gastric cancer (Horridge et al. 2017; Yamaoka et al. 2000, 2002).