The analysis of preoperative laboratory markers between children with perforated/gangrenous and uncomplicated appendicitis revealed a statistically significant difference with regard to WBC count (18.3 × 109/L vs. 13.9 × 109/L; p < 0.001) and CRP level (118.4 mg/L vs. 36.7 mg/L; p < 0.001) as shown in Table 2. The gene discussed is CRP; the disease is appendicitis.