The patients with perforated/gangrenous appendicitis were more commonly to be aged less than 5 years (12% vs. 3%; p = 0.02), experienced symptoms for more than 24 h (100% vs. 58%; p < 0.001), with body temperature more than 38.5°C (52% vs. 13%; p < 0.001), had a serum sodium level less than 135 mmol/L (90% vs. 6%; p < 0.001), and a CRP serum level more than 50 mg/L (71% vs. 17%; p < 0.001). The gene discussed is CRP; the disease is appendicitis.