Ligand-receptor configurations in both normal and psoriatic tissue are contained in Fig. s4a, with those showing increased signaling in psoriasis being selected and shown in Fig. 3A. For communications between fibroblasts and endothelial cells, TGFB, MIF and MK represented significant genes associated with communication, which were also computed with the NICHETET method. This evidence concerns the gene TGFB1 and psoriasis.