Immunohistochemistry analysis with antibodies against cancer markers Bcl-XL, EGFR, and Mct1, showed high positivity in tumor tissues derived from KO cells, unlike the mammary pads of mice injected with NM1 WT cells which don’t show any staining and tumors derived from KO + NM1 cells which only show dispersed staining of individual cells (Fig. 5E). This evidence concerns the gene EGFR and neoplasm.