By measuring the tissue level of cleaved caspase-3, the main effector caspase in the apoptotic pathway [65], we confirmed the proapoptotic effect of IND in the small intestine, although the rate of caspase-3 activation was only moderate, possibly due to the mild to moderate severity of enteropathy induced by the present experimental protocol. Here, CASP3 is linked to Abnormal intestine morphology.