Lin et al.105 showed that up-regulation of SLC26A3 prevented CRC growth and metastasis whereas down-regulation of SLC26A3 accelerated CRC progression by modifying the level of IκB expression, in addition, these researchers discovered that SLC26A3 expression was significantly decreased in tumor tissues as compared with normal tissue, which is consistent with our study. Here, SLC26A3 is linked to colorectal carcinoma.