Additionally, Mortezapour et al.87 using datasets from TCGA-COAD reported that MMP9, SERPINH1, COL1A1, COL1A2, COL5A1, COL5A2, and SPARC were significantly increased in colorectal cancer tissues compared to healthy tissues, which is in keeping with the finding of our study. This evidence concerns the gene MMP9 and colorectal cancer.