GUCA2A were significantly downregulated in tumor tissues compared with normal tissues (− 0.41-fold, p-value: 0.0007) (Fig. 9B) and COL3A1 were significantly upregulated in tumor tissues comparison with healthy tissues (7.18-fold, p-value: 0.0001) (Fig. 9D). Here, COL3A1 is linked to neoplasm.