Reactome enrichment analysis showed that key genes were mainly enriched in pathways related to innate immune system, Toll like receptor cascades, signaling by interleukins, IRAK4 deficiency TLR2/4 and regulation of TLR by endogenous ligand, diseases of immune system, interleukin 10 signaling, Toll like receptor TLR1/TLR2 cascade and antigen processing cross presentation (Fig. 10B). This evidence concerns the gene IRAK4 and immune system disorder.