CREB5 and hypercholesterolemia, familial, 1: Next, western blot analysis revealed that exogenous overexpression of miR-3913-5p resulted in the reduction of the CREB5 protein in LoVo and SW480 cells (Fig. 4c) and conversely, miR-3913-5p inhibition led to the increase of the CREB5 protein in FHC cells (Fig. 4d).