ANGPT1 and diabetes mellitus: There was a significant interaction of DM with Interleukin-18 receptor 1 and angiopoietin-1: HR per log2 [95% CI] for Interleukin-18 receptor 1 in DM 1.35 [1.08, 1.69] vs non-DM 0.77 [0.57, 1.1], P for interaction 0.008; HR [95% CI] for angiopoietin-1 in DM 0.78 [0.69, 0.87] vs non-DM 1.07 [0.90, 1.3], P for interaction <0.001 (Supplementary Data 8).