Neutrophil recruitment is the main mechanism by which IL-17 promotes infection-induced immunopathology in this setting; however, it also plays a minor role in mediating immunity against large multicellular parasites.140,141 In mice, IL-17 protects against the protozoan parasite—Trypanosoma cruzi—by attracting neutrophils that secrete the immunosuppressive cytokine IL-10, thereby reducing the generation of IFNs and inflammatory responses that can cause liver damage.142. This evidence concerns the gene IL17A and infection.