IFNA1 and tularemia: By targeting SIGLEC-F+ neutrophils with high NETosis activity and stimulating AMP synthesis, IL-17 plays a crucial role in the resolution of primary and secondary Bordetella pertussis nasal mucosal infections in mice.121 The role of IL-17 in preventing Francisella tularensis infection are indirectly mediated through promoting interferon (IFN) production, which improves macrophage-mediated bacterial killing;122 however, this likely reflects the flexibility of Th17 cells, leading to a shift towards IFN production.