Local tumor invasion, recurrence, and distant metastasis are the leading causes of drug resistance and poorer prognosis.300 IL-17-mediated signaling is associated with the migration and invasion of various malignant tumors, including oral squamous cell carcinoma,23 breast cancer,24 and gastric cancer.25 In addition, EMT can effectively promote tumor metastasis, recurrence, and drug resistance by enhancing the stem cell properties and mobility of tumor cells. The gene discussed is IL17A; the disease is cancer.