IL17A and neoplasm: Specifically, IL-17 produced by chronic inflammation induces the formation of a tumor microenvironment, and promotes tumorigenesis and cancer progression by remodeling the cellular stromal phenotype and inducing the production of inflammatory mesenchymal stem cells and mobilizing myeloid cells.285,286 Chronic inflammatory stimulation caused by recalcitrant pathogenic microbes is associated with dysregulated IL-17 production in the microenvironment.287 This prompts continuous attempts by the host immune system to control an uncontrolled immune response.