CARD14 and autoimmune disease: In addition, it interacts with other non-inflammatory cytokines, such as epidermal growth factor receptor (EGFR), fibroblast growth factor 2 (FGF2), caspase recruitment domain family member 14 (CARD14), and NOTCH to influence tissue repair, autoimmune diseases, and tumor development.80 Several signaling molecules interact synergistically with IL-17.