In patient-derived prostate cancer cells (“pCan1” and “pCan2”, from Dr. Mi [23]) and immortalized cell lines (PC-3/LNCaP), POLRMT mRNA expression is significantly higher than that in primary human prostate epithelial cells (“pEpi”, from Dr. Mi [23]) (Fig. 2E). Here, POLRMT is linked to Familial prostate cancer.