In our study, we utilized antibodies against both CEACAM6 (the predominant form of CEA in the protein family in CRC [22]) and pan-CEA to demonstrate that they are downstream effectors of ALDOB and/or aerobic glycolysis, which regulate cell proliferation and chemosensitivity by affecting glycolysis-mediated lactate production and secretion. Here, ALDOB is linked to colorectal carcinoma.