CDK6 and cancer: Regarding cellular functions, CDK6 knockdown also significantly inhibited cell viability (Fig. 5C), colony formation ability (Fig. 5D), and cell invasion (Fig. 5E) and elicited G0/1-phase arrest of cell cycle (Fig. 5F), whereas IGF2BP2 overexpression aggravated cancer cell aggressiveness (Fig. 5C–F).