CD8A and neoplasm: In connection with the potential participation of FLT3 in the response to mtPKCi-based combinations, FLT3 ligands foster mobilization of conventional dendritic cells (cDCs) in pancreatic ductal adenocarcinoma (PDAC) models to enhance CD8 + T cell and TH1 activity and, eventually, to reduce tumor growth and increase response to therapy55.