There is now, therefore, evidence that ZNF117 is implicated in a cellular preponderance for obesity-related effects, and from the association in the present study it is at least possible that rs67047829 itself, or a linked region, might change the upstream regulatory region for this gene (or, alternatively, ERV3-1 mRNA with rs67047829 might somehow affect ZNF117 mRNA processing as they share a common exonic region, in ways that are not fully understood). This evidence concerns the gene ERV3-1 and obesity due to melanocortin 4 receptor deficiency.